The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids
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چکیده
Shikimic acid and its role in the formation of aromatic amino acids, benzoic acids, and cinnamic acids is described, along with further modifications leading to lignans and lignin, phenylpropenes, and coumarins. Combinations of the shikimate pathway and the acetate pathway are responsible for the biosynthesis of styrylpyrones, flavonoids and stilbenes, flavonolignans, and isoflavonoids. Terpenoid quinones are formed by a combination of the shikimate pathway with the terpenoid pathway. Monograph topics giving more detailed information on medicinal agents include folic acid, chloramphenicol, podophyllum, volatile oils, dicoumarol and warfarin, psoralens, kava, Silybum marianum, phyto-oestrogens, derris and lonchocarpus, vitamin E, and vitamin K.
منابع مشابه
The shikimate pathway as an entry to aromatic secondary metabolism.
The shikimate pathway is often referred to as the common aromatic biosynthetic pathway, even though nature does not synthesize a11 aromatic compounds by this route. This metabolic sequence converts the primary metabolites PEP and erythrose-4-P to chorismate, the last common precursor for the three aromatic amino acids Phe, Tyr, and Trp and for p-amino and p-hydroxy benzoate (Fig. 1). The shikim...
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